Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis

Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in literature. Differentiating between medullary thyroid carcinoma and an ectopic source calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, unnecessary thyroidectomy This manuscript reports case hypercalcitonaemia from metastatic neoplasm concurrent pathology summarises results systematic review Medical Literature Analysis Retrieval System Online, Excerpta Medica, Cochrane Central Register Controlled Trials, ClinicalTrials.gov SCOPUS databases were systematically critically appraised all peer reviewed manuscripts that suitably fulfilled inclusion criteria established priori . The protocol this was developed according to Preferred Reporting Items Systematic Meta-Analysis Protocols , followed methods outlined Handbook Reviews Interventions is registered PROSPERO. It vital consider diagnoses other than when presented patient raised calcitonin, as it not pathognomonic carcinoma. Lung appear similar histologically, they secrete metastasize thyroid. Patients may show stimulated values over two or more times above basal values, whereas calcitonin-secreting response stimulation tests. present existing evidence neoplasms.